The Next-generation Sequencing (NGS) Market size was estimated at USD 8.5 billion in 2023 and is projected to reach USD 19.5 billion by 2030, exhibiting a compound annual growth rate (CAGR) of 12.20% during the forecast period (2024-2030).

Next-generation Sequencing (NGS) Market

Market Summary

The Next-generation Sequencing (NGS) Market represents a transformative segment within the biotechnology industry, fundamentally altering genomic research and clinical diagnostics. This technology enables the rapid and cost-effective sequencing of DNA and RNA, facilitating unprecedented insights into genetic variations, gene expression, and molecular mechanisms of disease. The market is characterized by continuous technological advancements that enhance sequencing speed, accuracy, and data output, making it indispensable for a wide range of applications from basic research to personalized medicine. Key industry participants are engaged in intense competition, driving innovation through the development of advanced sequencing platforms, reagents, and bioinformatics solutions. The adoption of NGS is expanding beyond academic and research institutions into clinical settings, pharmaceutical companies, and diagnostic laboratories, underscoring its critical role in advancing precision medicine initiatives globally. The market's evolution is further supported by growing investments in genomics research and increasing demand for high-throughput genetic analysis tools.

Key Highlights

The Next-generation Sequencing market is distinguished by several pivotal developments that underscore its dynamic nature. A primary highlight is the relentless innovation in sequencing technologies, leading to platforms capable of generating massive volumes of genetic data with remarkable speed and declining costs. This has democratized access to genomic information, enabling broader application across various sectors. Another significant aspect is the integration of artificial intelligence and machine learning with NGS data analysis, enhancing the interpretation of complex genomic datasets and accelerating biomarker discovery. The market is also witnessing a surge in strategic collaborations and partnerships among key players such as Illumina, Thermo Fisher Scientific, and Pacific Biosciences to expand technological capabilities and market reach. Furthermore, the increasing regulatory approvals for NGS-based diagnostic tests are facilitating their adoption in clinical practice, particularly in oncology and rare genetic disorders, marking a critical step towards routine clinical implementation.

Drivers, Opportunities & Restraints

Several powerful drivers propel the growth of the Next-generation Sequencing market. The escalating demand for personalized medicine, which tailors medical treatment to individual genetic profiles, is a fundamental force, as NGS is essential for identifying genetic mutations and biomarkers. Substantial government and private funding for large-scale genomics projects, such as population sequencing initiatives, further stimulate market expansion. Additionally, the declining cost of sequencing makes it more accessible to a wider range of users, from research labs to clinical facilities. Significant opportunities lie in the untapped potential of emerging applications, including non-invasive prenatal testing, infectious disease diagnostics, and agricultural genomics. The development of portable and benchtop sequencers also opens new avenues for point-of-care testing and decentralized laboratories. However, the market faces restraints, including the high initial investment required for advanced sequencing systems and the associated data storage and analysis infrastructure. Data management challenges, such as handling and interpreting the vast amounts of data generated, pose significant hurdles. Ethical concerns regarding genetic privacy and the lack of standardized protocols for certain applications also present obstacles to widespread adoption.

Concentration Insights

The Next-generation Sequencing market exhibits a concentrated competitive landscape, dominated by a few major players who hold significant market share due to their extensive product portfolios and technological expertise. Illumina maintains a leading position with its comprehensive range of sequencing instruments and consumables, supported by a strong global presence and continuous innovation. Thermo Fisher Scientific is another key contender, offering robust sequencing solutions through its Ion Torrent technology. Other notable companies include Pacific Biosciences with its long-read sequencing capabilities and Oxford Nanopore Technologies known for its portable sequencing devices. This concentration is characterized by high barriers to entry, including substantial R&D investments and complex intellectual property landscapes. However, the market also features numerous smaller firms and startups focusing on niche applications, specialized reagents, or bioinformatics software, contributing to a diverse ecosystem. Strategic mergers and acquisitions are common as larger entities seek to consolidate technologies and expand their market reach, further intensifying the competitive dynamics.

Type Insights

The Next-generation Sequencing market is segmented by technology type, each offering distinct advantages for specific applications. Whole genome sequencing provides a comprehensive analysis of an organism's entire DNA, making it invaluable for discovering novel genetic variants and understanding complex diseases. Targeted sequencing focuses on specific regions of the genome, offering a cost-effective and efficient method for analyzing known genes of interest, commonly used in cancer panels and hereditary condition testing. RNA sequencing is crucial for transcriptome analysis, enabling the study of gene expression patterns, alternative splicing, and non-coding RNAs, which is essential for research in developmental biology and disease mechanisms. Other emerging types include chromatin immunoprecipitation sequencing for epigenetics studies and metagenomics sequencing for analyzing microbial communities. The choice of sequencing type depends on the research question, desired resolution, and budget constraints, with ongoing advancements aiming to improve the accuracy, throughput, and affordability of each method.

Application Insights

Next-generation Sequencing finds diverse applications across multiple domains, significantly impacting research and clinical practice. In oncology, NGS is revolutionizing cancer care by enabling comprehensive genomic profiling of tumors to identify driver mutations, guide targeted therapy selection, and monitor treatment response through liquid biopsies. Genetic disease diagnostics leverage NGS to detect pathogenic variants in rare and inherited disorders, facilitating early intervention and personalized management strategies. Drug discovery and development benefit from NGS by identifying novel therapeutic targets, understanding drug mechanisms, and stratifying patient populations for clinical trials. Microbiology and infectious disease applications include pathogen identification, outbreak surveillance, and antimicrobial resistance genotyping. Agrigenomics utilizes NGS for crop improvement, livestock breeding, and disease resistance studies. Additionally, NGS is increasingly applied in forensic science, human identification, and consumer genomics, demonstrating its versatility and expanding utility across sectors.

Regional Insights

The adoption and growth of Next-generation Sequencing technology vary significantly across geographic regions, influenced by factors such as healthcare infrastructure, research funding, regulatory frameworks, and technological awareness. North America holds a prominent position in the market, driven by strong presence of leading sequencing companies, high healthcare expenditure, advanced research infrastructure, and supportive government initiatives in genomics. Europe follows closely, with robust academic research programs, increasing adoption of personalized medicine, and collaborative projects like the European Genome-phenome Archive. The Asia Pacific region is experiencing rapid growth due to rising healthcare investments, expanding biotechnology sectors, growing prevalence of chronic diseases, and increasing focus on precision medicine in countries such as China, Japan, and India. Latin America and the Middle East & Africa are emerging markets, where adoption is gradually increasing through international collaborations and efforts to enhance genomic capabilities, though challenges related to infrastructure and funding persist.

Company Insights

The competitive landscape of the Next-generation Sequencing market is shaped by key players who drive innovation and market growth through extensive research and strategic initiatives. Illumina is a dominant force, renowned for its sequencing platforms like NovaSeq and MiSeq, which offer high-throughput and accurate sequencing solutions, alongside a vast array of consumables and bioinformatics tools. Thermo Fisher Scientific competes strongly with its Ion GeneStudio S5 series and Ion AmpliSeq technology, focusing on scalability and ease of use. Pacific Biosciences specializes in long-read sequencing with its Sequel systems, providing advantages for resolving complex genomic regions. Oxford Nanopore Technologies offers unique portable sequencers such as MinION, enabling real-time, direct DNA and RNA sequencing in diverse settings. Other significant contributors include BGI Genomics, known for its large-scale sequencing services, and Agilent Technologies, which provides target enrichment solutions. These companies continuously invest in R&D to enhance sequencing accuracy, reduce costs, and expand application areas, while also engaging in partnerships to broaden their technological and market reach.

Recent Developments

The Next-generation Sequencing market is characterized by rapid technological advancements and strategic movements among key industry participants. Recent developments include the launch of novel sequencing platforms with enhanced capabilities, such as higher throughput, improved read lengths, and reduced error rates, making sequencing more efficient and accessible. There has been a significant focus on integrating automation and robotics into NGS workflows to streamline processes from sample preparation to data analysis, increasing reproducibility and reducing manual intervention. Key players have also expanded their product portfolios through acquisitions and collaborations, aiming to offer end-to-end solutions that include sequencing instruments, reagents, and advanced bioinformatics software. Furthermore, there is growing emphasis on obtaining regulatory approvals for NGS-based in vitro diagnostics, particularly in oncology and genetic testing, facilitating their adoption in clinical settings. Efforts to standardize protocols and ensure data quality are ongoing, alongside initiatives to address data storage and analysis challenges through cloud computing and AI-driven solutions.

Report Segmentation

This comprehensive market report on Next-generation Sequencing provides detailed analysis segmented across multiple dimensions to offer a holistic view of the industry. The segmentation by technology includes key methodologies such as whole genome sequencing, targeted sequencing, RNA sequencing, and other emerging approaches, each analyzed for their market dynamics and application suitability. Application segmentation covers critical areas like oncology, genetic diseases, drug discovery, microbiology, agrigenomics, and others, highlighting the diverse utility of NGS across sectors. The report further breaks down the market by end user, encompassing academic and research institutions, pharmaceutical and biotechnology companies, clinical laboratories, and other entities, detailing adoption trends and specific needs. Geographic segmentation provides regional analysis across North America, Europe, Asia Pacific, Latin America, and Middle East & Africa, examining local market drivers, challenges, and growth prospects. Additionally, the report includes segmentation by product type, distinguishing between sequencing platforms, consumables, and services, to address the varying components of the NGS ecosystem and their respective market performances.

FAQs

What is next-generation sequencing used for? Next-generation sequencing is utilized for a wide array of applications including genomic research, clinical diagnostics, personalized medicine, drug discovery, agricultural development, and infectious disease monitoring. It enables high-throughput analysis of DNA and RNA to identify genetic variations, study gene expression, and understand biological processes.

How does next-generation sequencing work? Next-generation sequencing works by fragmenting DNA or RNA samples into small pieces, attaching adapters, and amplifying them to create libraries. These libraries are then sequenced simultaneously in a massively parallel manner, generating millions of short reads that are computationally assembled to reconstruct the original sequence, providing comprehensive genetic information.

What are the advantages of next-generation sequencing? The advantages of next-generation sequencing include its ability to sequence entire genomes quickly and cost-effectively, high sensitivity and accuracy in detecting variants, scalability for various project sizes, and versatility across numerous applications from research to clinical diagnostics, facilitating advancements in precision medicine.

What is the difference between NGS and PCR? The primary difference between NGS and PCR is that PCR (Polymerase Chain Reaction) is a method used to amplify specific DNA sequences, while NGS is a high-throughput technology that sequences millions of DNA fragments in parallel, allowing for comprehensive genomic analysis beyond targeted amplification.

How much does next-generation sequencing cost? The cost of next-generation sequencing varies based on the scope of the project, sequencing technology used, and depth of coverage required. Expenses encompass sample preparation, sequencing runs, and data analysis, with prices generally decreasing over time due to technological improvements, making it more accessible for diverse applications.

What are the types of next-generation sequencing? Types of next-generation sequencing include whole genome sequencing for full genomic analysis, targeted sequencing for specific regions, RNA sequencing for transcriptome studies, epigenetics sequencing for modifications, and metagenomics sequencing for microbial community analysis, each serving distinct research and diagnostic purposes.

Citius Research has developed a research report titled “Next-generation Sequencing (NGS) Market Report - Global Industry Analysis, Size, Share, Growth Trends, Regional Outlook, Competitive Strategies and Segment Forecasts 2024 - 2030” delivering key insights regarding business intelligence and providing concrete business strategies to clients in the form of a detailed syndicated report. The report details out the factors such as business environment, industry trend, growth opportunities, competition, pricing, global and regional market analysis, and other market related factors.

Details included in the report for the years 2024 through 2030

• Next-generation Sequencing (NGS) Market Potential
• Segment-wise breakup
• Compounded annual growth rate (CAGR) for the next 6 years
• Key customers and their preferences
• Market share of major players and their competitive strength
• Existing competition in the market
• Price trend analysis
• Key trend analysis
• Market entry strategies
• Market opportunity insights

The report focuses on the drivers, restraints, opportunities, and challenges in the market based on various factors geographically. Further, key players, major collaborations, merger & acquisitions along with trending innovation and business policies are reviewed in the report. The Next-generation Sequencing (NGS) Market report is segmented on the basis of various market segments and their analysis, both in terms of value and volume, for each region for the period under consideration.

Next-generation Sequencing (NGS) Market Segmentation

Regions Covered

• North America
• Latin America
• Europe
• MENA
• Asia Pacific
• Sub-Saharan Africa and
• Australasia

Next-generation Sequencing (NGS) Market Analysis

The report covers below mentioned analysis, but is not limited to:

• Overview of Next-generation Sequencing (NGS) Market
• Research Methodology
• Executive Summary
• Market Dynamics of Next-generation Sequencing (NGS) Market
  • Driving Factors
  • Restraints
  • Opportunities
• Global Market Status and Forecast by Segment A
• Global Market Status and Forecast by Segment B
• Global Market Status and Forecast by Segment C
• Global Market Status and Forecast by Regions
• Upstream and Downstream Market Analysis of Next-generation Sequencing (NGS) Market
• Cost and Gross Margin Analysis of Next-generation Sequencing (NGS) Market
• Next-generation Sequencing (NGS) Market Report - Global Industry Analysis, Size, Share, Growth Trends, Regional Outlook, Competitive Strategies and Segment Forecasts 2024 - 2030
  • Competition Landscape
  • Market Share of Major Players
• Key Recommendations

The “Next-generation Sequencing (NGS) Market Report - Global Industry Analysis, Size, Share, Growth Trends, Regional Outlook, Competitive Strategies and Segment Forecasts 2024 - 2030” report helps the clients to take business decisions and to understand strategies of major players in the industry. The report delivers the market driven results supported by a mix of primary and secondary research. The report provides the results triangulated through authentic sources and upon conducting thorough primary interviews with the industry experts. The report includes the results on the areas where the client can focus and create point of parity and develop a competitive edge, based on real-time data results.

Next-generation Sequencing (NGS) Market Key Stakeholders

Below are the key stakeholders for the Next-generation Sequencing (NGS) Market:

• Manufacturers
• Distributors/Traders/Wholesalers
• Material/Component Manufacturers
• Industry Associations
• Downstream vendors

Next-generation Sequencing (NGS) Market Report Scope

COVID-19 Impact Analysis

Like most other markets, the outbreak of COVID-19 had an unfavorable impact on the Next-generation Sequencing (NGS) Market worldwide. This report discusses in detail the disruptions experienced by the market, the impact on flow of raw materials, manufacturing operations, production trends, consumer demand and the projected future of this market post pandemic.

The report has helped our clients:

• To describe and forecast the Next-generation Sequencing (NGS) Market size, on the basis of various segmentations and geography, in terms of value and volume
• To measure the changing needs of customers/industries
• To provide detailed information regarding the drivers, restraints, opportunities, and challenges influencing the growth of the market
• To gain competitive intelligence and uncover new opportunities
• To analyse opportunities in the market for stakeholders by identifying high-growth segments in Next-generation Sequencing (NGS) Market
• To strategically profile key players and provide details of the current competitive landscape
• To analyse strategic approaches adopted by players in the market, such as product launches and developments, acquisitions, collaborations, contracts, expansions, and partnerships

Report Customization

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